IM-21 by Mike Tyson Reviews: Iron Matrix Burn AM and Build PM Supplements

IM-21 is a Mike Tyson-endorsed supplement designed to help in burning fats and building muscles. Daily consumption of IM-21 Burn and IM-21 Build can purportedly maximize your all-day focus, energy levels and strength, better sleep, quicker recovery, and overnight growth.

If you are new to the supplement world, like most first-timers, you probably wonder whether the supplement is good for you, whether it lives up to the hype, and is worth your money and time. Here is everything you need to know about IM-21 and how it works.

What is IM-21?

IM-21 is a nutritional formula available online on the manufacturer’s website at IM-21.com. Daily consumption of the supplement can purportedly trigger your body’s growth mode and allow you to enter your prime by providing it (your body) with the vital powerhouse nutrients necessary for building muscles and burning fats. The product is neither a protein powder nor a pre-workout supplement but a combination of two supplements designed to achieve target performance in multiple ways as follows:

IM-21 Burn

IM-21 Burn is a powdered formula designed to promote your all-day focus and superior strength while giving you explosive energy. It comprises caffeine and other powerful ingredients proven to boost all-day performance. You should mix it with water and take it daily for the best results.

IM-21 Build

IM-21 Build is a sleep and restoration powder you mix with water and take daily for better, longer, deeper, and more restorative sleep. It is also helpful for promoting faster recovery, growth, and other related perks.

As people grow older, it becomes harder for their bodies to maintain the growth stage, including yours, resulting in stress and depression. Fortunately, IM-21 is here to help you. It contains a blend of energy and anabolism boosting ingredients such as creatine, caffeine, and calcium HMB and sleep aid ingredients including melatonin, valerian, and L-tryptophan. The goal is to keep your body full of energy during the day and enjoy quality and quantity of sleep at night, which is the time your body undergoes a powerful muscle-building process.

IM-21 Benefits

Taking IM-21 daily can purportedly help you in the following notable ways:

  • More strength
  • Faster metabolism
  • Better sleep
  • Less body fat
  • Quicker muscle gains
  • Improved focus
  • More motivation

The formula also claims to help people struggling with a slow metabolism, muscle loss, sleep problems, slow muscle gains, excessive body fat, low motivation, fatigue, and brain fog, among other related issues. These challenges are linked with poor training and performance levels due to insufficient energy during the day. IM-21 works by maximizing your day energy, which is responsible for solving the above issues.

How to Use IM-21

IM-21 powders, Build and Burn, come in powdered form, which you mix with water and take daily to enhance your muscle growth and performance. Here are the manufacturer’s recommended steps on how to use the formula as highlighted on the official website:

Mix the IM-21 powder with water. Both Burn (AM) and Burn (PM) are easily soluble in water – use about 8 to 10oz of water. But you can also consider milk, milkshake, or your favorite beverage for a different experience.

Enjoy a tasty anabolic drink: As you get older, your body requires a little force to put and maintain it in the growth mode. The drink from IM-21 is filled with nutrients and amino acids necessary for growing your muscles, making it ideal for attaining your body’s optimal growth.

Activate the Growth Mode: The IM-21 supplement drink contains powerful anabolic activators that trigger your body into an incredible fat-burning and muscle-building state and maintains it day and night for as long as you keep taking the supplement.

IM-21 Ingredients

IM-21 is a perfect blend of powerful ingredients proven to support fat burning and muscle building. Mike Tyson refers to these ingredients together as the iron matrix formula and gets them from trusted sources to guarantee you and other users amazing results. The active ingredients in IM-21 are as follows:


It is one of the essential and proven sports performance supplements today. It has been thoroughly researched, with findings showing that it is a powerful muscle builder making it the second best-selling supplement globally after whey protein.


It is clinically tested and proven as a powerful ingredient for growing and maintaining incredible strength and muscle mass based on IM-21. The supplement’s official website described HMB as possibly the leading anabolic element in the world, every gram counts.

Vitamin D3

The element is useful for the growth of muscles and stronger bones. It works effectively in combination with HMB and creatine, with some studies showing that increasing your vitamin D intake by 20% can increase your strength immensely.


This fruit sugar is absorbed into the body and converted into glycogen. The latter is necessary for the growth of muscles, and combining it with creatine, boosts your body’s retention and absorption rates.


It is another active ingredient in IM-21 and is known for being the first amino acid to be discovered. It is found throughout the body and plays a vital role in muscle performance and energy.

Protease (Papain)

IM-21 contains a form of papain known as protease. The latter is a digestive enzyme that breaks down proteins, making it easier for the body to absorb, process, and utilize the proteins you consume from the supplements. IM-21 is perfect for people struggling with bloating and discomfort, especially after taking a supplement.


L-Glutamine is another form of amino acid that is abundant in the body. It is useful in supporting muscle tissue growth and performance regardless of the ongoing stress in the body.


It is another active ingredient in IM-21, which supports energy levels in the body by balancing digestion. For this reason, it is common in most drinks.


Caffeine is a tested and proven fat burner and energy booster making it a leading supplement ingredient today. It helps boost your energy levels and focus throughout the day making it an essential component in IM-21.


It is a vital amino acid required by the body for effective performance. Sadly, it must be artificially induced, as the body cannot manufacture it by itself as it is with other essential amino acids. You can get this amino acid from either the relevant foods or supplements such as IM-21 that contain the element.

B Vitamins

IM-21 contains three B vitamins, namely B2, B6, and B12. Your body requires these vitamins to support energy metabolism, digestion, and other related body processes. Vitamin B12 is excellent for vegetarians or people on a vegan diet considering that there are no excellent plant-based sources of vitamin B12. Taking these daily guarantees you a daily intake of the required amounts of B vitamins, which means high energy levels and focus.

IM-21 contains vitamin C, which is one of the most powerful natural antioxidants. It is also an incredible immune booster, just like other antioxidants. A daily intake of vitamin C through IM-21 improves your immunity and faster recovery from injuries after workouts and skin issues, among other perks.


It is one of the ancient ingredients used in making Chinese medicine for centuries now. It is a type of mushroom used as an adaptogen – it improves your body’s speed of responding to stress. The research team at IM-21 explains that cordyceps in the supplement are great at regulating blood sugar while improving cellular energy (targets ATP production), boosting stamina, and improving energy levels, among other benefits.


GABA is a vital amino acid for your brain health and function. Your brain is packed with GABA receptors and taking a GABA-rich supplement such as IM-21 allows your brain to receive adequate GABA through the bloodstream. The adequate GABA supply to your brain enhances rest relaxation and better sleep.

IM-21 includes GABA among its active ingredients in the Build formula to calm your mind and eventually sleep well all night long. As your body strives to build and develop muscles at night, GABA ensures that your body maximally benefits by ensuring a deep rest.


This ingredient is another popular herbal extract used in most sleep aid supplements, thanks to its powerful relaxation properties. It is rich in valerenic acid, which inhibits the breakdown of GABA in the brain. Regular consumption of the element guarantees you quality rest and faster recovery throughout the night.


Melatonin is one of the active ingredients in IM-21 popular for its amazing sleeping properties. The human body produces melatonin based on its sleep-wake cycles, known as the circadian rhythm. In case of disruption in the latter, the body finds it hard to sleep due to its compromised ability to produce melatonin.

For this reason, most people struggling with sleep problems take melatonin supplements to help resolve their issues. The 3mg dose of melatonin in IM-21 is adequate to trigger faster and deeper sleep without any side effects.


This amino acid is popularly known for supporting sleep and relaxation. It is the prominent ingredient in turkey meat that makes people feel sleepy after the meal. Most sleep ingredients use to promote rest and relaxation among users.

IM-21 Features

IM-21 carries a range of useful features, making it superior to protein powders, HRT, and creatine. According to information on the official website, this supplement boasts of the following attractive properties:

  • It requires no prescription unlike HRT
  • It has no side effects
  • It activates anabolic pathways contrary to protein powder and creatine
  • It is a tested and proven fat burner
  • It is a proven muscle builder
  • It makes your food anabolic
  • It is simple, safe, and easy to use
  • It supports better sleep and anabolic recovery
  • It provides true cellular fuel
  • It provides clean, all-day energy
  • It comes with a lifetime moneyback guarantee

Scientific Evidence for MI-21

IM-21 Build and Burn have not completed their clinical trials to verify their effectiveness. Nevertheless, both of them come with scientific proof to support their intended goals – use science-backed ingredients. The manufacturer cites numerous studies to validate the many ingredients that they use in making the formula. Here are some of the reviews to support the science behind IM-21.

One study about IM-21 involved numerous participants who were taking beta-hydroxy-beta-methyl butyrate (HMB). HMB is one of the active ingredients in IM-21. It makes the product unique from creatine supplements and protein powders as it’s only used in the former.

The participants gained 252% more lean body mass (7.4lbs) than 2.1lbs by the control group after 12 weeks. Another study showed participants who gained their one-rep max by 18% within five days, which translates to a 200% improvement compared to a placebo. According to the researchers, HMB consumption has no side effects and the participants further enjoyed increased strength and hypertrophy besides incredible resistance during training.

That study further states that the participants received either 3g or 5g of creatine daily, after which they were tested for maximum muscle strength (1RM), upper body endurance (MPU), and abdominal muscle endurance (MSU) after one week, two weeks, three weeks, four weeks and 35 days. The participants recorded significantly better measurements across all performance measurements except for abdominal muscle endurance, which remained the same.

IM-21 also purports to support testosterone increment. Thanks to these key conditions for achieving the latter, you can increase your testosterone by promoting better sleep and increased energy.

One study showed that participants who used the supplement for one year gained 25% more testosterone. The researchers further told 165 participants to take vitamin D or a placebo for one year, 54 men. While the vitamin D group showed a significant increase in testosterone levels, the placebo group showed no improvement.

IM-21 also cites a study proving that the ingredients used in the formula are proven to support deep sleep. The study shows that the valerian participants recorded an 18% increase in sleep quality compared to the control group. The group of 16 patients suffering from sleep issues took valerian or a placebo, and the former spent more time in deep sleep and fell asleep quickly.

IM-21 can also boost endurance. The manufacturers of this supplement cite a study in which cordyceps Sinensis, a mushroom extract used in making the formula increases endurance by up to 79% when taken independently and 139% when used with other endurance boosters.

The study claimed to analyze the effectiveness of traditional Chinese medicine, and the researchers gave 200mg/kg doses of cordyceps to some rats for 15 days. The rats given the element recorded significantly better endurance compared to the control group.

Generally, IM-21 comprises a range of ingredients proven to support recovery, anabolism, energy levels, and muscle building. The formula should work as advertised in two different ways to help you boost your overall performance even if you don’t achieve as powerful results as Mike Tyson.

IM-21 Ingredients Label

Mike Tyson and his team at IM-21 are open and upfront about their ingredients in making the formula. The openness and honesty make it easier to compare the product with other energy and sleep supplements available on the market. Here are some of the ingredients available in the IM-21 formula.


Each packet of Burn weighs (7.1g) and contains the following ingredients:

  • 100mg of calcium (7% DV)
  • 1.3mg of vitamin B2 (100% DV)
  • 65mg of vitamin B6 (3,500% DV)
  • 40mcg of vitamin B12 (1,666% DV)
  • 45mg of vitamin C (50% DV)
  • 5,000 IU / 50mg of vitamin D3 (625% DV)
  • 75mg of caffeine
  • 1,500mg of creatine
  • 2mg of fulvic acid
  • 100mg of glycine
  • 500mg of HMB (calcium HMB)
  • 100mg of L-glutamine
  • 40mg of phenylalanine
  • 200K USP of protease/papain (2,000USP/mg)
  • 100mg of taurine
  • Other (inactive) ingredients, including fructose, citric acid, orange flavor, and sucralose

Each packet contains 12 calories, 0g of fat, 0g of sodium, and 3g of carbs.


Each packet of Build weighs (6.2g) and comprises the following ingredients:

  • 100mg of calcium (7% DV)
  • 5,000 IU/ 50mg of vitamin D3 (625% DV)
  • 10mg of cordyceps
  • 1,500mg of creatine
  • 2mg of fulvic acid
  • 100mg of GABA
  • 100mg of glycine
  • 500mg of HMB (calcium HMB)
  • 40mg of L-tryptophan
  • 3mg of melatonin
  • 200K USP of protease/papin (2,000USP/mg)
  • 50mg of valerian root extract
  • Other (inactive) ingredients, including fructose, chocolate fudge flavor, and sucralose

Each packet contains 12 calories, 0g of fat, 0g of sodium, 0g of potassium, and 3g of carbs.

IM-21 Pricing

IM-21 is available at $69 per package. The package is designed to serve you for one month and contains Burn and Build. However, you can save money by ordering multiple packages as follows:

  • 1 Month Supply: $69 + $6.95 Shipping
  • 3 Month Supply: $177 + Free US Shipping
  • 6 Month Supply: $234 + Free US Shipping

IM-21 Refund Policy

IM-21 offers a lifetime moneyback guarantee. If you find the product unsatisfactory, you can contact the company at 866-GET-IM21 (866-438-4621) for an easy and stress-free refund as long as you send back the unused product.

About IM-21

IM-21 is a health and nutrition company founded by Mike Tyson, a former undisputed heavyweight global champion. The company’s flagship product, IM-21, comprises two categories: Burn and Build; besides following GMP-certified guidelines and is manufactured in the U.S.

The company’s name originates from 21 active ingredients used in making the formula. Coincidentally, Mike Tyson was also 21 in 1987 when he unified the three heavyweight titles.

IM-21 was founded based on the Iron Philosophy that involves burning away your weakness, demanding the best from your body, and building true strength, which requires you to push yourself forward regardless of the challenges constantly.

Final Word

IM-21 is a nutritional supplement designed to support anabolism, energy levels, muscle building, and relaxation. Daily consumption of the supplement can guide you towards achieving your targets in two ways thereby optimizing your growth.

The manufacturer offers a lifetime moneyback guarantee on all purchases and gives users confidence in every purchase. Visit the company’s official website at IM-21.com for all inquiries by clicking here! >>>


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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team. Please know we only recommend high-quality products.


Please understand that any advice or guidelines revealed here are not even remotely substitutes for sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Make sure to consult with a professional physician or financial consultant before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary and are not guaranteed as the statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The efficacy of these products has not been confirmed by FDA, or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any kind of get-rich money scheme. Reviewer is not responsible for pricing inaccuracies. Check product sales page for final prices.

The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

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