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Best NAD+ Supplements to Buy in 2021 (Top NAD Boosters List)

In the modern world, NAD+ boosters are increasingly becoming popular as anti-aging supplements. We have worked with many people of different ages, and in the process, we have identified a few supplements that are helpful to some of our older clients.

Some research studies claim that NAD+ supplements help with anti-aging and life extension. The action mechanism of NAD+ supplements targets aging at a cellular level, thus stimulating anti-aging effects throughout the users’ entire bodies. NAD+ supplements are thought to increase energy production in the mitochondria. Therefore, the more NAD+ available in your body, the more cells you will have to work with, leading to better cell function.

Also known as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), NAD+ boosters are widely available across principal stores worldwide. There are several NAD+ boosters in the market today. Determining which is right for you is a daunting task for any prospective buyer. Keep reading to discover everything you need to know about NAD+ and anti-aging supplement health benefits.

Best NAD+ Boosters for 2021

To differentiate hype from science, our editorial team contacted manufacturers and clients alike to test the benefit claims of some of the best NAD+ supplements available today. After a rigorous research process, here is a recommended list of the best NAD+ supplements for you to compare in 2021:

  • Tru Niagen
  • Life Extension NAD+ Cell Regenerator
  • HPN Supplements NAD+3 NAD+ Booster
  • Alive By Science
  • Quicksilver Scientific Liposomal NAD+ Gold
  • Elysium
  • Liftmode NMN
  • RiboGEN
  • Cymbiotika NMN
  • Toniq NMN
  • NR Chloride Powder

Tru Niagen

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Tru Niagen Nicotinamide Riboside is one of the most studied NAD+ supplement brands you will find around, and that is backed by science. It is no wonder that the brand is one of the best-known on our list. Subject to over ten clinical studies, Tru Niagen manufacturers claim that the product contains up to 500 mg of NR for a good reason – to promote cellular repair and increase energy production.

According to research studies, a single serving of Tru Niagen can increase NAD+ levels by 80%. This is the reason the brand has been consistently a big name over other NAD+ boosting supplements. Most clients say positive things about Tru Niagen, with the majority applauding its efficiency in increasing motivation and performance at the gym or during any exercise.

300 mg and 500 mg concentrations are the most common and can be purchased in counts of 30, 90, 0r 180 per bottle. Buyers can take advantage of the bulk discounts offered for the supplement. The more you are buying, the more you can save.

Life Extension NAD+ Cell Regenerator

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Life Extension is a well-established company that strives to provide quality supplements using the best dosages and ingredients across its hundreds of supplements. With over three decades in the industry, the company has managed to design its anti-aging supplement using NIAGEN® nicotinamide riboside in such a way that it helps the cell regeneration process by promoting NAD+ production levels in the cells.

Like many other NAD+ supplements that will follow in our list, Life Extension NAD+ Cell Regenerator formulation contains 300 mg of NR per serving. There is another option of 100 mg per capsule. Life Extension is a good option as they are a brand that many people trust.

If their claims are anything to go by, Life Extension contains additional ingredients to increase the effects. These can promote mitochondrial health, reduce fatigue at a cellular level, and promote consistent cellular energy production. What’s more, it comes at a discounted price, offering similar ingredients to other better-value NAD+ boosters in the market.

HPN Supplements NAD+3 NAD+ Booster

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Advertised as Fountain of Youth,” NAD+3 boosters by HPN are supplements that have also received positive reviews from clients for their ability to improve various aspects of life. The unique formula of the supplement takes a different approach from other types in our list to create its NAD+3 proprietary blends.

Instead of using NR or NMN products, the formulation combines theacrine (an extract from the wasabi plant), copper, and niacin in the ionic compound copper nicotinic acid, all of which purportedly boost NAD+3 levels, to create the supplement. According to the company, the supplement can help reduce cell inflammation, increase telomerase activity for aging, activate cell detoxification, increase NAD+ levels for mitochondrial functions, among other benefits.

Every serving of NAD+3 delivers 311 mg of the unique formula. Because there is a higher prevalence of copper deficiency in older adults, NAD+3 is a good bet if you look to improve copper deficiency.

Alive By Science

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Alive By Science is among the biggest manufacturers of NAD+ products in the United States. The company holds a high reputation for its adherence to safety standards in manufacturing its NAD+ products, which must undergo at least four rounds of purity testing before being released into the market.

Stomach acids degrade most NMN capsules. With that in mind, Alive By Science has come up with innovative delivery mechanisms to increase absorption. The brand offers the most different forms of NMN in our list, including transdermal, intranasal, sublingual, and liposomal products in capsule or powder forms.

As the NAD+ industry continues to blossom, Alive By Science has reduced its manufacturing costs leading to a slash of prices up to 15%. From $50 to $80, an Alive By Science NAD+ supplement bottle is convenient for unique anti-aging needs and comes in multiple tastes and preferences.

Quicksilver Scientific Liposomal NAD+ Gold

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There are a few companies that sell NAD+ and NMN products online today. One such company is Quicksilver Scientific which offers a popular NAD+ booster supplement called NAD+ Gold. Quicksilver has consistently produced high-quality products in truism, and they left no stone unturned with their NAD+ liposomal.

According to the manufacturers, the supplement effectively boosts NAD+ levels, leading to healthy aging, increased cognition, and high energy levels. Using a unique liposomal delivery mechanism, the supplement ensures that most of the active ingredients in the formulation end up in the bloodstream.

Interestingly, Quicksilver Scientific’s liposomal formula behaves the same way as the body’s transport system for NMN. With that having been said, it means that the supplement is a fountain of your youth in a bottle. To take the anti-aging liposomal supplement, just press two pumps into your mouth and then hold them for 30 seconds before swallowing.

Elysium Basis

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Elysium is a reputable company that has an impressive array of scientific advisors and a team of committed employees dedicated to creating a supplement that understands and improves your health as you age. The supplement features clinically proven trials that show it can increase NAD+ levels by up to 40% in people.

The supplement contains several essential ingredients, including B-vitamin complex, omega-3 fatty acids, antioxidants, and anthocyanins, to rapidly increase NAD+ levels in the body. Each Elysium capsule contains 125 mg of nicotinamide riboside. The package comes with a biological age test kit so that you can follow on your progress. Does the supplement succeed?

After a thorough research by our team, we discovered that Elysium is one of the few NAD+ booster supplements backed by recent scientific discoveries. As a supplement, Elysium is safe for human consumption. It is vegan, vegetarian, nut-free, gluten-free, and contains no artificial flavors or colors.

Liftmode NMN

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Liftmode is another popular company when it comes to smart drugs and nootropics. The formulation contains 10 mg of nicotinamide mononucleotide per 100 servings. NMN has recently gained popularity due to its perceived anti-aging effects similar to NR.

Studies have demonstrated that NMN is a synthetically produced nucleotide that can alleviate NAD+ levels in the body leading to increased energy metabolism. Additionally, NMN is known for improving cognitive function in the aging brain by increasing NAD+ production in this region.

With a typical serving size of around 25 mg per jar, Liftmode NMN is easy to customize your dose however you like. With evidence suggesting that you expect a natural decline in NAD+ levels as you age, Liftmode is an excellent option to increase cellular energy levels, sharpen cognitive functions of the aging brain, and provide powerful regenerative effects, among other benefits.

The supplement comes in a transparent and sealable jar to increase potency.


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RiboGen is one of the strongest and best-selling products in the market today. The manufacturers claim their formula is pure pharmaceutical-grade nicotinamide with no additives to maintain NR’s purity in clinical and medical studies.

Like other supplements listed here, RiboGen is a precursor to NAD+ production. It means that its goal is to provide your body with the necessary ingredients required to increase NAD+ levels. At 99.5% nicotinamide riboside concentration and a 0.5% NAM, it is clear that RiboGen is a no-nonsense NAD+ boosting supplement that warrants a mention in this review.

In comparison to other NAD+ boosters in our list, RiboGen seems more expensive at $300. However, once you overcome the sticker shock, you will realize that it is the most affordable per dose. Each bottle contains 300 capsules which means the pricing drops down to just $1.10 per serving – a price usually only available to doctors, clinics, and vitamin shops.

Cymbiotika NMN

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Cymbiotika NMN is also another popular product on our list. The NMN formula combines the benefits of NMN supplementation with added antioxidants and polyphenols to boost NAD+ levels throughout the body. Our product research was particularly excited that Cymbiotika uses the highest quality of organic, bioavailable, and wild-crafted ingredients in its formulation.

Apart from NMN as the active ingredient, there are also complementary ingredients like a green coffee bean, resveratrol, apigenin, green tea extract, and more. Supplementation of Cymbiotika NMN is believed to offer energy revitalization, improved cognitive health, protection from aging, and improved cellular metabolism.

The company recommends two capsules a day alongside your daily dose of Cymbiotika Magnesium L-Threonate for an even more synergistic effect.

Toniiq NMN

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This is a fantastic product by Toniiq. Over the years, the company has been committed to producing quality products by using certified and approved state-of-the-art manufacturing facilities to create their supplements. Each serving of Toniiq NMN capsules contains 300 mg of a highly purified form of NMN to promote longevity and healthy aging.

Priced at just $45 per bottle, Toniiq NMN has been individually tested by manufacturers and third parties alike to ensure the supplement is free from additives, impurities, and contaminants. Each bottle contains 60 or 180 capsules of 99%+ pure NMN to give your body the precursors it requires to produce more NAD+.

Another exciting feature about the Toniiq NMN supplement is that it has the best-looking packages compared to other supplements on our list. It comes in a shelf-stable non-refrigerated form sealed in black bottles to block moisture, light, or oxygen, thus ensuring maximum potency. NR Chloride Powder

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At under $30, offers clients the most potent form of nicotinamide riboside (NR) in our list. According to the manufacturers, each batch of NR supplement has been tested and approved for quality and safety. You can take the supplement in powder form as a capsule – or mix it as needed to enjoy its full NAD+ boosting effects.

The supplement is priced at $30 per bottle, making it one of the most affordable NR supplements on the list. To prevent degradation, the jar has a protective layer against UV light.

How We Ranked the Top NAD+ Supplements for 2021

Some NAD+ booster manufacturers claim many additional benefits for their products, such as inducing anti-aging effects but hardly deliver even their core purpose. Therefore, we came up with a list of metrics to help distinguish the scams from the legit as follows:

Proven Ingredients

The effectiveness of NAD+ supplements begins with their ingredients, where we ensured that only those with proven components were included on this list. NR and NMN are the two most critical ingredients that we looked out for as they are proven to be the most effective.

Strong Doses

Whether an NAD+ booster has the right ingredients, misuse can either lead to side effects or no effects at all. So we also ensured that besides having the right ingredients, they consisted in the right amounts for maximum effectiveness and safety.


Manufacturers who use unapproved formulae will want to hide critical information from the users. On the other hand, legit manufacturers will always be proud of the components information labeled on their products. Therefore, we ensured that we only included products with proper, transparent labeling.

Complementary Ingredients

Ingredients such as resveratrol and turmeric have been proven to also contribute to the NAD+ boosting effects. Their inclusion only means the products will have higher effectiveness. However, we also did not exclude products that lacked such ingredients.

Manufacturer’s Reputation

While many companies only produce products for economic reasons, some have invested enormous amounts of money and time in testing and upgrading their products to ensure that consumers get the maximum benefit. Such brands earn a good reputation for satisfying consumer needs and delivering their claims. So we also prioritized recognized brands with a good reputation over beginners whose intentions are unclear.

Price & Value

Different people have different spending limits for NAD+ boosting. However, some manufacturers may go overboard with their prices. Despite including a range of prices, we ensured that each product provided enough value for their costs.

Advertised Benefits

When it comes to winning a market, some NAD+ booster manufacturers will promise exaggerated benefits such as age reduction by decades. Others will claim to reduce enormous weight in a matter of days. We were wary of such manufacturers and only ensured we included those with logical claims.

Human Clinical Trials

While most companies only base their claims on studies conducted on the ingredients, some have conducted human trials to verify their products’ effectiveness on people. Therefore, such products are often more accurate with their advertised benefits.

Top 4 Benefits of NAD+ Boosters

Besides their core purpose, many NAD+ boosters come with multiple additional benefits. Here are some benefits you might get from a consistent supplementation with NAD+ boosters:

Combat Age-Related Memory Loss

Old age comes with a natural decline in memory. However, an effective NAD+ booster can counteract the condition by relieving neuronal stress and repairing DNA. Many people have testified to improvements in memory after using NAD+ boosters.

Weight Loss

Several studies have proven that NAD+ supplementation may help manage weight by boosting metabolic processes to control fat accumulation from diets. For example, one study found that NR, a common NAD+ booster ingredient, reduced weight gain by 60% while increasing energy in mice under high-fat diets.

Reverse the Effects of Aging

Although NAD+ boosters cannot reverse your age rapidly, their long-term usage has been found to affect various age factors positively. In one study, two-year-old mice supplemented with NAD+ ended up producing matching tissues with four-month-olds that were not supplemented. This is an indication that NAD+ has a counteractive effect on the aging of tissues. Many people use NAD+ boosters to control aging, and they have been successful.

Boost Muscle Strength and Endurance

NAD+ boosters have also been found to have a positive impact on muscles. Different studies have linked NAD+ boosters to muscle growth and DNA repair. They can also increase endurance at the cellular level. Top 5 Natural Ways to Boost NAD+ Levels

Although taking NAD+ boosters is the easiest way to boost your levels, studies imply that specific changes in diet and lifestyle can also increase your NAD+ levels.

Natural Ways to Help Boost NAD+ Levels

These are the five most scientifically proven practical ways to boost your NAD+ levels:

  • Restrict Calories: Reducing your calorie intake by as little as 20% to 30% can increase your natural NAD+ levels.
  • Fast or Practice Intermittent Fasting: Research has proven that fasting can also increase NAD+ production in the body. You can combine fasting and a reduction in calorie consumption for increased longevity and healthy aging.
  • Prevent Sun Damage: Excessive exposure to the sun may cause skin damage, which the body uses NAD+ to repair. This depletes NAD for use by other critical body functions and contributes to aging. It is recommended to wear protective clothing and sunscreen to minimize the damage for higher NAD levels.
  • Practice HIIT Workouts: High-intensity Interval Training has long been known to improve mitochondria health. However, increasing studies imply that this type of training can also moderate the consumption of your NAD+ or increase your levels. It can also improve your growth hormone.
  • Follow a Healthy Diet: Insufficient nutritional composition causes a problem producing various compounds such as NAD+. Maintaining a sufficient consumption of nutrients such as vitamins and minerals can ensure you undergo a healthy and controlled aging process.

Top Best Diets for Boosting NAD+ Levels

Research shows that sticking to specific diets can be effective in boosting NAD+ levels in body cells. For example, restricting calories, fasting, and following a keto diet can help increase NAD+ levels. Our team suggests the following types of foods if you are looking to boost your NAD+ levels naturally:

  • Fish: Perhaps the main reason most people eat tuna, sardines, and salmon daily, fish meat is rich with precursors to NAD+, necessary for anti-aging effects.
  • Green Vegetables: Green vegetables contain the vitamins, nutrients, and minerals that the body requires to produce NAD+ and other essential compounds.
  • Milk: Research indicates that milk is a good source of nicotinamide riboside (NR) that is naturally available. A glass of milk daily will go a long way into ensuring you stay healthier and younger.
  • Yeast and Whole Grains: Vitamin B3 is a crucial vitamin that is primarily found in whole grains. These vitamins do not exist in processed grains, and like yeast, they contain nicotinamide riboside – a precursor to NAD+.

Scientific Facts about NAD+ Booster Supplements

Without a doubt, NAD+ boosters are becoming popular in the contemporary world due to their validated health benefits. Researchers agree that NAD+ boosters can boost energy and provide powerful anti-aging effects throughout the body. However, further research needs to be done to verify the claims.

In an animal research study involving a group of mice, results suggested that NAD+ levels could improve your muscle strength and lifespan. The specifically-bred mice were given an NR supplement during the research, while another group was strictly put under a placebo.

After some time, the mice in the NR group presented several health benefits. They had minor DNA damage, less neuronal damage, increased production of neurons, and higher neuroplasticity, among others. As more research on humans continues to be conducted, we will learn with time whether these benefits can be translated to people.

NAD+ Boosters Associated Side Effects

There are no significant side effects associated with NAD+ booster supplements. Like many other supplements sold on online platforms today, NAD+ boosters are tested and approved for safety before being released into the market. In other words, they are generally recognized as safe (GRAS) by the FDA. As long as users stick to the dosage instructions, the ingredients pose no harm to the body.

Depending on the NAD+ brand you are taking, the side effects profile might vary. The common side effects associated with most of these supplements include flushing, itching, abdominal pain, elevated liver enzymes, and vomiting.

If you have an existing medical condition or are under any kind of medication, you should consult your doctor before taking an NAD+ booster or any other supplement for that matter.

NAD+ Boosters Recommended Dosage

Many NAD+ boosters contain a dose of 300 mg concentration of either NMN or NR. Research studies indicate that such a concentration is meaningful in raising NAD+ levels within the cells. Similar studies suggest that doses as small as 100 mg can induce similar effects, while quantities of up to 500 mg enhance the impact of NAD+ even further.

FAQs about NAD+ Boosters

Q: What is NAD+?

A: NAD stands for nicotinamide adenine dinucleotide, a coenzyme in body cells and vital in cell metabolism. It exists in two forms, namely, NAD+ and NADH.

Q: What is NMN?

A: NMN stands for nicotinamide mononucleotide, one of the two significant precursors to NAD biosynthesis.

Q: What is nicotinamide riboside (NR)?

A: Similar to NMN, NR is a precursor of NAD+ biosynthesis. In other words, NR is incorporated in NAD+ booster supplements to boost NAD+ production in the cells.

Q: What are the symptoms of low NAD+ levels?

A: When you have low NAD+ levels in your body cells, the apparent biological reason is that your cells have a reduced ability to synthesize energy. You start feeling lethargic and may not feel mentally and physically active as you used to be in your younger days.

Q: Can NAD+ booster supplements help with conditions such as Alzheimer’s?

A: There is no clinical evidence to back this claim. However, circumstantial evidence from animal models and biochemistry studies suggests that increasing NAD+ levels could help alleviate the condition.

Q: How do you differentiate between NAD, NAD+, and NADH?

A: NAD is a vital coenzyme found in all cells to aid in cell metabolism. It exists in two forms – NAD+ and NADH. The former is the NAD form that serves all functions throughout the cell, while the latter is the NAD form that cannot perform all processes throughout the cell.

Q: Does food contain NAD+?

A: Although NAD+ contents in food cannot be directly absorbed into the body, NAD+ precursors such as nicotinamide riboside, tryptophan, and vitamin B3 contained in foods such as turkey, milk, fish, yeast, and mushrooms can activate NAD+ production in cells.

Q: What is the role of NAD+ in the body?

A: NAD+ is essential for multiple roles in the cell. Specifically, it helps transform nutrients that we ingest into adenosine triphosphate (ATP), which is the fuel required by cells to produce energy.

Q: Why does NAD+ reduce with age?

A: The natural body mechanism allows cells to continuously produce more NAD+ to sustain the energy levels required for growth and well-being. Unfortunately, as you get older, NAD+ production levels in the cells reduce.

Q: Do NAD+ in the body cells have anti-aging effects?

A: As you age, NAD+ levels in the body cells decline. NAD+ booster supplements hold the potential to boost energy and reduce aging-related signs. NAD+ supplements achieve this goal by focusing on specific mechanisms of aging instead of cosmetic treatment methods, which only focus on particular manifestations of the skin.

Q: Which is better for boosting NAD+ levels in body cells? NMN or NR?

A: According to research studies, NR NAD+ boosters are better compared to NMN NAD+ boosters because the latter is too big for your body to absorb.

Q: Which NAD+ supplements are the most effective?

A: Recent research shows that the best NAD+ supplement in the market today is based on nicotinamide riboside (NR) because nicotinamide riboside is rapidly absorbed into the bloodstream to act as precursors of NAD+ production.

On the other hand, NMN or nicotinamide mononucleotide shows promising results in animal studies but is yet to be translated to humans. That is why our top-ranked NAD+ supplements include the likes of Tru Niagen, Elysium Basis, among other nicotinamide riboside-based supplements.

Best NAD+ Boosters for 2021 Final Words

NAD+ is essential for cellular energy production. Administering NAD+ supplements into your body helps in various ways, including weight loss, increased cellular energy, and improved cognition, among other benefits.

NAD+ booster supplements increase NAD+ levels and its metabolites in the most vital parts of your body, such as the heart, to sustain better body functioning even in old age.

ALSO READ: Best 12 Testosterone Booster Supplements: 2021 Buyer’s Guide

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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