Best Digestive Enzymes That Work (2022) Compare Top Brand Picks

If you’ve ever had a meal & felt bloated, indigestion, or cramping for hours afterward, you know how awful it is. But what if you could take a pill and have these problems vanish? On the other hand, digestive enzyme supplements claim to eliminate bloating and cramping caused by gastrointestinal disorders, allowing you to enjoy your favorite foods without the unpleasant side effects. But do they deliver their promises?

Your digestive system is made up of many organs that function together.

These organs break down the food & liquids you consume into simpler forms, including proteins, carbohydrates, lipids, and vitamins. The nutrients are then delivered to the circulation via the small intestine, offering energy for repair and growth. Digestive enzymes are required for this process because they break down lipids, proteins, and carbohydrates into smaller molecules that can be absorbed more quickly.

Digestive enzymes are created naturally when your body is in proper operating condition to promote digestion by breaking down and absorbing nutrients. These digestive enzymes are produced naturally by the pancreas, which secretes a different enzyme for each macronutrient: amylases for carbs, lipases for fats, and proteases for proteins.

On the other hand, the body isn’t always able to keep up. You’ll get bloating, gas, and digestive issues as a result. Lactase deficit is a common digestive enzyme shortage that inhibits lactose (milk sugar) from being broken down. Another overall deficiency is a lack of alpha-galactosidase, which aids in the breakdown of carbohydrates in legumes and beans.

Digestion enzymes supplements, which are readily accessible over the counter, are frequently the solution. These can be an excellent and dependable treatment for various gastrointestinal issues, such as IBS, low stomach acid, and age-related enzyme deficiency. Despite this, there is little evidence to support the use of enzymes as a general digestive aid, and most of the research to date has focused on prescription-only supplements.

The Top 7 Digestive Enzyme Supplements

Below is a list of the best digestive enzyme supplements available in the 2022 market:

  • EnzymeMD
  • DigestWell
  • Onnit DigesTech
  • Zenwise Health Digestive Enzymes
  • AlphaZym Plus
  • Vital Plan Active Enzymes
  • EnzyBurn



EnzymeMD is a digestive support product that works quickly to relieve discomfort caused by bloating, indigestion, & gas, particularly after meals.

The supplement contains a combination of 18 plant-based digestive enzymes & probiotics that aid in the restoration and maintenance of digestive health.

EnzymeMD is made by a Board-Certified Gastroenterologist, ensuring quality and efficacy. It’s a high-potency solution that includes 18 digestive enzymes.

Assist with the natural breakdown and absorption of essential nutrients.

The probiotic S. boulardii inhibits the production of gas & toxins in the digestive system. It works quickly to relieve the discomfort caused by indigestion, bloating, & gas after eating.

EnzymeMD merely aids in the neutralization of gas produced in the stomach. Its primary purpose is to improve and maintain a healthy digestive system. One method the supplement may assist is converting difficult-to-digest meals into helpful energy in the body.

It also contains prebiotics and other ingredients that help maintain healthy gut flora. It’s also worth noting that regular usage of this solution assists digestion by minimizing bacterial fermentation, making digesting tough.

1MD, an American firm that focuses on dietary supplements to improve lifespan and overall health, is the manufacturer of EnzymeMD. The company thinks that the key to its success is combining science and nature. 1MD also takes pride in employing only the most potent substances and working in certified facilities to ensure that its customers receive only the best health products. The designer of EnzymeMD claims that this supplement offers everything you need to aid in the digestion of sugar and carbs, fats & triglycerides, proteins, and peptides.

EnzymeMD Proprietary Blend is a proprietary blend created by EnzymeMD. There are 18 enzymes in the mix.

  • Saccharomyces Boulardii
  • Alpha-amylase
  • Bromelain
  • Peptidase
  • Glucoamylase
  • Proteases
  • Papain
  • Alpha-galactosidase
  • Cellulase
  • Lipase
  • Beta-glucanase
  • Phytase
  • Invertase
  • Maltase
  • Hemicellulase
  • Xylanase
  • Lactase

Bromelain and papain are allergens in this product and are prone to cause allergic reactions in people allergic to pineapples or papaya.

Gluten-free Celiacs shouldn’t have any issues with this product because it’s gluten-free.

There are no genetically modified components in this product. In addition, none of the probiotic strains have been genetically engineered.



DigestWell is a one-of-a-kind solution that blends digestive enzymes, probiotics, & plant ingredients that are known to calm and improve the gut. It reduces bloating & gas while improving nutrient absorption, making your gut—and you—happy and healthy.

That’s because not only does most of our modern food lack crucial digestive components like fiber and enzymes, but it’s also clean. That is, sterilizing products, extensive hand washing, and a lack of time spent in the soil have restricted our access to the beneficial bacteria required for proper digestion. Bloating, gas, constipation, diarrhea, and a leaky gut are possible side effects.

Yes, DigestWell can assist with symptoms of weak digestion on its own, but why stop there? However, combining DigestWell with a diet rich in fresh fruits and vegetables, water, and perhaps even some time in the dirt might help you get your digestion back on track. Taking other measures in addition to this product will not only improve your digestion right away but will also provide a long-term, holistic approach to digestive health.

Digest Well contains papain, bromelain, lipase, amylase, lactase, and cellulose, as well as other plant-based enzymes. It’s a one-of-a-kind blend that helps you digest protein, carbs, fats, and lactose.

The formula is as follows:

  • Amylase is a digestive enzyme that participates in carbohydrate breakdown.
  • Bromelain is a protein-digesting enzyme.
  • Cellulase is a digestive enzyme that aids in the digestion of fiber.
  • Lactase – aids in the digestion of lactose in dairy products.
  • Lipase is a digestive enzyme that aids in the digestion of lipids.
  • Papain is a digestive enzyme that aids in the digestion of proteins.
  • Digestive enzymes derived from plants aid in digesting protein, fat, carbs, starch, dairy, and fiber.
  • Support a healthy digestive system and intestinal flora.
  • Inflammation in the intestines should be reduced.
  • Fast-Acting Digestive Support is a DigestWell benefit.

Bloated guts are not only gassy and unpleasant, but they may also be explosive. Hence it is designed to help with gas and bloating.

Being gassy is not only inconvenient, but it can also be a sign of a weakened stomach owing to a lack of fiber, beneficial bacteria, & digestive enzymes.

DigestWell, on the other hand, provides the optimal balance of ingredients for reducing indigestion, which produces gas and bloating.

Onnit DigesTech


Onnit’s DigesTech is a full-spectrum digestive enzyme supplement that includes protease, amylase, and lipase, among the best and most proven digestive enzymes currently available.

The benefits of these three substances are listed below:

Protease is a digestive enzyme that breaks down proteins and digests and removes toxins and pollutants from the body, which helps cleanse the system.

Amylase is a carbohydrate-digesting enzyme that breaks the chains of sugar molecules, converting them to glucose that can be used to energize and nourish the body.

Lipase is required because dietary lipids are too big for the body to absorb. This fat-digesting enzyme breaks down lipids to be absorbed more easily by the body, specifically through the intestinal lining.

Onnit DigesTech’s Advantages:

DigiTech has the advantage of working with the enzymes already present in the stomach to break down food more quickly. As a result, folks who take the supplement will not experience such uncomfortable pains.

Another advantage of Onnit DigesTech is that the enzymes in the supplement aid in nutrient absorption. Humans require food to keep their bodies functioning properly and provide them with the vitamins, minerals, and other nutrients they need to flourish.

Finally, DigesTech helps people with a variety of digestive issues. Everybody is unique, reacting differently to various nutrients and chemicals. Some people have trouble digesting dairy, while others have trouble digesting carbohydrates.

Onnit DigesTech: How To Use It

DigiTech has no adverse effects because it only has natural and safe ingredients. However, health experts advise against taking more than 6 DigesTech capsules in 24 hours, as the supplement’s contents are potent and may overwhelm the system.

It is recommended that those new to DigesTech take two capsules at the start of each meal. If users new to DigesTech do not want to take it for every meal at first, they can begin by taking it with their largest meals and gradually adding the additional portions to their other meals.


At the start of your meal, two capsules are the suggested dosage for adults. Each bottle has 60 capsules, so if you take two every day, each bottle should last you 30 days. You should not take any more unless a healthcare professional has instructed you it is okay to do so.

Zenwise Health Digestive Enzymes


Zenwise Health Digestive Enzymes is a popular product among those seeking the benefits of a digestive enzyme supplement and more, as it contains 230-233mg of probiotics and prebiotics (L-Salivarius, L-Plantarum, L-Acidophilus), which feed probiotics. The advanced enzyme formula includes 350mg of protease, papain, amylase, lactase, and bromelain, to name a few. Ginger, Apple Pectin, Wakame, Green Papaya, Turmeric, Bladderwrack, Inulin, and Fennel are other constituents beneficial to inflammation and digestion.

This product contains all-natural, plant-based enzymes that aid digestion and alleviate IBS and other stomach discomfort symptoms. In the health industry, there are numerous digestive assistance dietary supplements. This review seeks to differentiate Daily Digestive Enzymes from comparable items in this health category and assess the likelihood of help.

Thanks to Zenwise Health’s Advanced Multi Enzyme System, you don’t have to avoid hard-to-digest meals like raw, spicy, fried, and processed foods, as well as dairy and acidic fruits and vegetables. It may help with gas, bloating, and discomfort when taken before meals. Daily Digestive Enzymes is a supplement that aids in the digestion and absorption of fats, carbs, proteins, and cellulose. This allows the food-carrying tract to function more efficiently and without causing problems like bloating, loose and frequent stools, pain, gas, and discomfort.

Zenwise Health Digestive Enzymes is made up of the following ingredients:

  • Papaya (green)
  • Pectin from apples
  • Turmeric
  • Peppermint
  • The complex of Sea Vegetables
  • The complex of Pre/Probiotics
  • Fennel is a type of fennel that (Seed)
  • Vegetable Cellulose is a type of cellulose that comes from plants (Capsule)
  • Cellulose Microcrystalline
  • Magnesium Stearate is a kind of magnesium salt.
  • Silicon Dioxide (SiO2).
  • Ginger
  • System of Advanced Enzymes

Even though the enzymes are gluten-free, these are not recommended for celiac patients. It’s a concern to have too few probiotics, but it’s also a concern to have too many in the stomach. Zinc, a well-known IBS remedy, would have been expected to be included. There is no single treatment for all Irritable bowel syndrome (IBS) in most cases. Whether you have loose stool, constipation, cramps, or gas is determined by your symptoms.

AlphaZym Plus


Are you looking for the best digestive enzymes to aid weight loss? If that’s the case, you might want to check out what AlphaZym has to offer.

AlphaZym Plus is a digestive enzyme supplement that goes after the source of obesity. It will help the gut by providing a variety of proven nutrients that will help it handle food more efficiently. As a result, your gut will have no trouble breaking down the more complex foods.

The AlphaZym Plus product website opens with a traumatic narrative from the formula’s developer, as do most supplement websites. Jonathan Grim says that he didn’t have a weight problem until 37. He was diagnosed with a “rapid weight increase” at this age. Grim’s efforts to reclaim his health and wellness got increasingly tricky as the pounds began to pile on. Finally, he concluded he was only touching the surface of his weight gain. Grim began researching strategies to attack the problem at its root to enhance his health and eliminate the extra weight.

The ingredients are psyllium powder, Acai berry fruit extract, inulin, aloe powder, chlorella, and slippery elm bark. All of the waste will be pushed out of the system by these ingredients. And because there would be less waste in the intestines, fat will not settle as efficiently. Some of the substances also help to detoxify the whole body. As a result, your intestines will absorb more vitamins than usual. In addition, the blend contains digestive enzymes that assist healthy inflammation. The best part is that you won’t have to spend a fortune to get all of these advantages.

These types of sales presentations are typical in the weight loss supplement industry. Thousands of new items have emerged from entrepreneurs and researchers worldwide in the last several years. Almost all of them promise to be essential to help customers lose weight without exercising or giving up their favorite foods. Truthfully, weight loss is a complicated process requiring hard work, regardless of the supplements.

Vital Plan Active Enzymes


Plan for Success The digestive enzyme mix in Active Enzymes targets the digestive system’s comfort and traction function. Plant-based substances that have undergone thorough research and are well-proven will help to assist the digestive system. A licensed physician also creates it. This adds to the overall credibility. Active Enzymes is one of the few recipes produced by a professional medical doctor, and it includes cardamom and fennel for an added digestive boost. Dr. Bill Rawls, a medical doctor (MD) with decades of expertise practicing medicine, created the supplement.

Alpha Galactosidase, digestive enzyme lipase, a slew of exogenous enzymes, and others are the digestive enzymes. Because there are no levels of the enzyme lactase in the formula, it will not cause lactose intolerance. The digestive tract and the entire system will benefit from the digestive enzymes. These will help your system get the most out of the digestive enzymes by improving absorption. Furthermore, each purchase is protected by a cash-back guarantee, making it risk-free.

Plan for Success Active enzymes can assist naturally in boosting digestive health. It contains 15 organic digestive enzymes that help your body break down food and absorb nutrients more efficiently.

Vital Plan’s Active Enzymes, which contains 15 plant-based digestive enzymes, are more potent than other digestive products, including 450-470 mg of enzymes per dose. Cardamom seed and fennel seed are among the additional ingredients. Since they break down food digestion, these enzymes can naturally aid digestive health. These capsules, which are doctor-formulated and plant-based, help with digestion.

Features that have been highlighted:

  • Developed by a physician
  • It contains digestive enzymes derived from plants.
  • A money-back guarantee is included.
  • Alpha Galactosidase, exogenous enzymes, and many more ingredients are incorporated.
  • It has fennel and cardamom in it.



Some people’s functions slow down as a person gets older. When a person reaches the age of 40, the body no longer processes nutrients as efficiently as before. Despite the slower digestion of calories consumed, the body requires the same degree of appetite. As a result, most people gain weight and lose their body shape from this age onwards. EnzyBurn is a digestive enzyme supplement that costs $49 a bottle and can only be purchased from the company’s official website. The supplement was created using data from a “lost community of island inhabitants” who live 100 years while being slim, happy, and healthy.

Most traditional fitness and weight loss regimens are only effective for individuals under 40 because they ignore the body’s ongoing changes. Fortunately, tools like EnzyBurn are available to assist those who wish to get back into shape rapidly, even after turning 40. The islanders were thin, healthy, and happy for hundreds of years, according to the manufacturers. They’ve also developed a digestive enzyme blend to put in their diet. EnzyBurn, in other words, comprises enzymes derived from plants.

EnzyBurn is a probiotic pill that claims to aid weight loss by clearing out harmful bacteria and pollutants from the digestive tract. The product was created with the importance of the gut in supporting the immune system and facilitating proper absorption of all nutrients ingested by the user in mind. Digestive enzymes help your body break down the things you eat. Intestinal health and digestion are dependent on digestive enzymes. If you lack particular enzymes, your body may struggle to get down carbs, proteins, and other food components. Some doctors recommend digestive enzyme supplements for those who have digestive problems.

You won’t have to worry about lactose intolerance difficulties because the active enzymes are all-natural enzymes. It will not cause any digestive issues or pain. On the other hand, the ancient formula will fill your stomach with natural enzymes that promote digestion. The combination of natural digestive enzymes is also available in a vegetable capsule. The digestive system will have no trouble extracting all-natural digestive enzymes. In addition, after consuming this digestive enzyme supplement, the digestive system will absorb nutrients from foods much more swiftly.

EnzyBurn may be the ideal choice for you if you believe in the power of traditional medicine. It’s popular among those who desire to lose weight by using digestive enzymes. Although some of the claims (such as losing significant weight without exercise or dieting) appear to be overblown, EnzyBurn can help you achieve your weight reduction objectives by providing a proven digestive enzyme mix.

How We Ranked The Top Digestive Enzyme Supplements

Supplements of Digestive enzymes help in food digestion, nutrient release, and removal of unwanted toxins from the body. The primary purpose of digestive enzymes is to support the endocrine system and distribute all nutrients. Digestive enzymes also work to balance cholesterol and triglycerides in the body, which can help with various health issues.

People may have difficulties deciding which digestive enzyme supplement to utilize due to the many options accessible. Potential customers typically inquire about which digestive enzyme is the best and any side effects while using the supplement.

The digestive supplements are quite helpful and are highly suggested for people of all ages, young and old, healthy and sick – in other words, everyone. These supplements consist of various ingredients that can boost your immune system, aid digestion, and even treat illnesses.

It may appear that selecting digestive enzyme supplements is simple. In truth, finding digestive enzymes that work is a challenge. To cut down the list, we had to do a lot of research, look at a lot of clinical trials, & compare a lot of digestive enzymes.

This is what it goes like:

Enzyme Count in the Digestive System

Various digestive enzymes break down foods. Protein is broken down by protease, while carbohydrates are broken down by amylase. There’s no reason why a digestive enzyme supplement can’t include a variety of digestive enzymes. 10 to 15 digestive enzymes were found in the highly-rated digestive enzyme supplements.


The supplements of Digestive enzymes will only be helpful if they make it to your intestines. The highest-rated digestive enzyme supplements have an enteric coating that helps them tolerate stomach acid. The more active digestive enzymes are, the more varied the outcomes. Some digestive enzyme solutions will not deliver tangible benefits even when utilizing recognized digestive enzymes at the recommended dosages. The formula’s failure to move through the gastrointestinal tract is the reason. That’s why, even though different digestive enzyme products had the exact dosages, one came out on top.

However, the enteric coating will be used in some digestive enzyme supplements. This allows them to withstand the stomach acid. As a result, all digestive enzymes are delivered to their proper locations. Only if the digestive enzymes have a greater endurance rate will you enjoy dynamic benefits.

Reputation and History of the Manufacturer

Some supplement manufacturers have a history of creating high-quality products. Other businesses are new and unproven. Some supplement companies rely on third-party laboratory tests, while others simply believe their item is as pure as it claims to be. We considered the manufacturer’s reputation and their honesty while deciding our rankings.

Rather than focusing on them, we focus on the goods from well-known brands. Those brands are usually prominent and have been on the market for an extended period. And, in majority cases, they received all of the credit for providing high-quality goods.

Digestive Enzymes That Have Been Proven

For the digestive enzymes, you’re purchasing a digestive enzyme supplement. As a result, we prioritized the numbering factor over all others. You expect a digestive enzyme supplement to have proven digestive enzymes when you buy one. The recipe was the first test that the digestive enzyme vitamins had to pass. Without established digestive enzymes, no digestive enzyme blend will optimize digestion, much alone provide other benefits.

However, not all enzyme supplements provide identical established digestive enzymes. Some have tonnes of enzymes, while others have a sufficient number of digesting enzymes. In addition, the digestive enzyme supplements with the most confirmed digestive enzymes received a higher overall score in our ranking.

Benefits Promised

Digestive enzyme substances will not assist you in losing 30 pounds in 7 days or in diabetes prevention or any other disease that could turn out to be one of the life-threatening situations. Digestive enzymes are an essential part of a healthy and balanced diet and become a way of life. Researchers were suspicious of digestive enzyme goods that made unsubstantiated claims. The advertised benefit of excellent digestive enzyme vitamins was straightforward and truthful.

Similarly, no digestive enzyme supplements would be able to protect you from dangerous diseases. On the other hand, many digestive enzyme supplements will rely on these marketing methods to make them appear too good to be true.

So always remember that if digestive enzyme solutions appear too good to be true, they most likely are. However, we did not consider digestive enzyme supplements that used exaggerated marketing methods. Instead, we chose digestive enzymes that were upfront about the advantages they could provide.

Clinically Effective Doses

In the world of digestive enzyme supplements, dosages are varied. It’s not as straightforward as comparing milligrams to milligrams. On the other hand, specific amounts have been shown to work in trials while other numbers have not. In ranking digestive enzyme supplements, we looked for those that used potent, clinically-effective concentrations of multiple established enzymes.

Several digestive enzyme supplements on the market have the proper blend of enzymes but don’t function as well as they should. Do you have any idea why? The digestive enzyme doses on those formulations are incorrect. As a result, we looked at the dosages of each digestive enzyme contained in the digestive enzyme supplements. Comparing digestive enzymes in milligrams against milligrams, on the other hand, is a complex undertaking. However, determining whether the digestive enzyme contains clinically established dosages is relatively simple.

Value & Price

However, in this section, the researchers stress good value at all pricing points. We wanted you to obtain decent components even if you bought a low-cost supplement. We also expected premium supplements to be of premium quality at a premium price.

Formulated by a Doctor

Doctors, qualified dietitians, and other professionals designed some of the top digestive enzyme substances on our list, providing them an edge over competing goods. Digestive enzyme supplements validated by qualified medical opinion or knowledge were chosen. EnzymeMD, our top digestive enzyme supplement, was created by a board-certified gastroenterologist!

Available Satisfaction or Money-back Policies

Since you won’t feel digestive enzyme capsules, you won’t detect if they’re working. Nevertheless, all efficient digestive enzyme supplements come with a cash return policy. You should be able to receive a refund if your digestive enzyme supplementation did not give any good results or even if you were dissatisfied with your order for any reason. We looked for digestive enzyme supplement companies that offered a money-return guarantee.

Natural digestive enzymes are replaced with replacement digestive enzymes, which aid in breaking down carbohydrates, lipids, and proteins in the foods you eat. The nutrients are then absorbed into your body through the small intestine wall and transported via the bloodstream.

As a result, digestive enzyme replacements can aid in preventing malabsorption and accompanying digestive discomforts.

Substitute digestive enzymes must be taken before you eat because they’re designed to replicate your natural pancreatic enzymes. They’ll be able to conduct their job as soon as the meal reaches your stomach and small intestine.

How Does The Digestion Process Happen?

Eating and drinking are two activities that seem to come naturally to most people. You do things daily without much thinking. What happens within your body after you eat, on the other hand, is complicated. The digestive process extracts the energy you need to function and then excretes the rest.

When you chew and swallow, your body goes through a well-coordinated series of activities that you are unaware of. Peristalsis is a muscle activity that propels food through your digestive tract involuntarily. It’s a crucial step in the digestive process. This action resembles an oceanic wave attempting to push food from one organ to another on an X-ray. Food travels down your food pipe in the first step of this journey. It travels from your throat to your stomach this way.

The lower esophageal sphincter is the valve that allows food to pass into your stomach. As needed, this ring-shaped muscle opens and shuts the passage between your esophagus and stomach. The sphincter relaxes during digestion, allowing food to flow into your stomach. Food passes through your stomach for a large portion of the digestion process. Your stomach may appear to you as a simple pouch. It is, however, far more robust than the rest of your body’s organs. Your stomach produces the digestive acids and enzymes to break down food. The stomach is also quite adaptable. The top region of your stomach relaxes and expands as your most recent food arrives.

During digestion, muscles push food from the upper to the lower portion of your stomach. This is the point at which the real action begins. The food you chewed and swallowed is broken down here by digestive fluids and enzymes. It prepares it to supply energy to your body. Several digestive juices and enzymes are produced in the stomach and mixed with food. The stomach’s powerful muscles then work as a mixer, blending the food into a usable form.

For certain foods, this procedure takes longer than for others. Carbohydrates, for example, are the most easily broken down. The stomach contents gently move into a small tube at the stomach base once it has completed its job in the digestive process. The duodenum is the name for this part of the digestive tract. It’s the small intestine’s first section. The next stage of digestion occurs here. Converting food into energy is continued by digestive juices created in organs such as the liver & pancreas.

Signs and Symptoms of Low Digestive Enzyme Counts

Symptoms of an enzyme deficiency include:

  • Digestive problems
  • Nutrient absorption is poor.
  • Obesity and weight gain
  • Immune system deficiency
  • Fatigue
  • Anxiety and sadness
  • Problems with the skin
  • Diarrhea
  • EPI causes diarrhea because undigested food remains in the small intestine. Fats and other nutrients cannot be absorbed when the pancreas fails to create the essential digestive enzymes. Instead, they stay in the small intestine, absorbing water and causing diarrhea.
  • Loss of weight
  • You may lose weight if your body cannot absorb adequate nutrients and fats. People who have a digestive problem in addition to EPI, such as Crohn’s disease, are more likely to have this.
  • Pain in the abdomen
  • The discomfort is commonly felt in the right upper part of the abdomen and can be mild or severe.
  • Symptoms not related to the gastrointestinal tract
  • Vitamin deficiencies can result from a lack of ability to absorb essential nutrients, leading to non-digestive symptoms.

What are the Common Digestive Enzymes?


Pancrelipase is available under Creon, Pancreaze, Pertyze, & Viokace. Pancrelipase is made of the enzymes lipase, amylase, & protease. The pancreas produces enzymes that aid in the digestion of lipids, proteins, and carbohydrates.


Lactaid & Lactaid Ultra are two brands of lactase available. Lactose, or milk sugars, are broken down by this enzyme in dairy products.


Beano and Gas X Prevention include the alpha-galactosidase, also known as alpha-d-galactosidase. This enzyme breaks down complex carbohydrates into simple sugars to avoid gas, bloating, and stomach irritation. It aids in the digestion of certain meals, such as beans.


Pancreatin is a protein that contains protease, amylase, & lipase enzymes. It aids in the breakdown of lipids, carbohydrates, and proteins. Hi-Vegi-Lip, Pancreatin 4x, Donnazyme, & Digipepsin are all drugs that include it.


Sacrosidase is a yeast-based enzyme that helps with sucrose digestion. It’s indicated for persons who don’t have the enzyme sucrase & can’t break down sugar. Sucraid is a product that contains it.

Top Benefits of Digestive Enzymes

Even though research into the health advantages of supplemental digestive enzymes is still ongoing, several studies have claimed that digestive enzymes are beneficial to one’s health. Let’s look at a few of the advantages of using digestive enzymes.

Increases Nutrient Absorption

The fundamental function of digestive enzymes in your body is to increase nutrient absorption. If you take digestive enzymes, you will extract more from your diet. Without these digestive enzymes, the nutrients you eat won’t break down in your gut, and you will become gassy.

Increases Your Energy

Because the nutrients you obtain from food are correctly utilized, you may notice that you have more energy. Dormant absorption depletes the body’s energy supply, which may be used for other metabolic processes. Digestive enzymes can aid in converting carbohydrates into glucose, the energy-giving sugar molecule. A supplement with amylase may help you convert sugars into fuel more efficiently.

Preventing Leaky Gut

The nutrients in your meal are absorbed by the tiny cells that line the lining of your intestines. When food isn’t adequately digested, larger, undigested molecules might push and break through cell membranes, causing your immune system to go into overdrive to combat these “invaders.” This can lead to inflammation in the lining of your intestines and other parts of your body. This isn’t good.

Clearer Skin

It can show up on your skin if you’re not getting the nutrients you need or if you’re suffering inflammation inside your body. Fatty acids, for example, are an essential component of healthy skin, & we acquire them from food! It will show that the outside of your body isn’t getting adequate nutrition on the inside.

Improved Memory and Mental Focus

Serotonin and dopamine are two neurotransmitters that are frequently associated with the brain. However, our digestive tract produces 90% of the serotonin we have. Start with your gut if you’re feeling foggy or need a productivity boost.

Methylation is Encouraged

Methylation is a biological process in our DNA during cell division and synthesis. It’s responsible for various bodily functions, including detoxification, inflammation control, and energy production. Because our systems rely on B vitamins for this process, it’s more difficult to absorb them if our digestion isn’t up to par or if our digestive tract has an overgrowth of bacteria.

Reduced Chronic Fatigue & Pain

Inflammation is frequently the source of discomfort. Headaches and migraines might be linked to gut inflammation, which in turn can be connected to a nutritional deficiency. The pancreatic digesting enzyme amylase, in particular, turns carbs into glucose, a vital chemical our bodies utilize for energy. So, if your digestion is in good shape, you’ll probably notice a difference in the rest of your body as well.

Reduced IBS Symptoms

Another common consequence of improper food deconstruction is that bacteria in your intestines may begin to feed on it. Bloating, gas, cramps, diarrhea, and other characteristic IBS symptoms can occur when this bacterium is overfed and overgrown. Inflammation in the gut is also linked to Crohn’s disease and ulcerative colitis. According to preliminary research, digestive enzymes can aid with food sensitivities & disorders such as lactose intolerance.

Reduced Inflammation

According to research, proteolytic enzymes, including bromelain, may protect your system from excessive inflammation. Proteolytic enzymes break down hazardous pathogenic complexes that otherwise cause your immune system to create unnecessary inflammation.

Proteolytic enzymes have also been shown to minimize edema and enhance circulation. This improves your body’s ability to provide oxygen and nutrients to the area while also transferring dangerous waste materials away.

Hypochlorhydria Relief

Low hydrochloric acid levels can lead to malabsorption of some minerals, such as B12, resulting in anemia and exhaustion symptoms. If you have a shortfall in hydrochloric acid, you can help build it up by taking a digestive enzyme supplement.

What are the Recommended Digestive Enzyme Dosages?

Prescription digestive enzymes are often required for people who have been diagnosed with an enzyme deficiency. These supplements aid the body’s digestion and absorption of nutrients. Pancreatic enzyme replacement treatment is the most prevalent and only FDA-regulated enzyme replacement therapy (PERT). PERT combines amylase, lipase, and protease that your doctor will prescribe. It aids in the digestion of carbohydrates, lipids, and proteins.

Many people take over-the-counter digestive enzyme supplements for acid reflux, gas, bloating, and diarrhea symptoms.

Amylase, lipase, and protease may be present. Lactase and alpha-galactosidase are present in some. Galactooligosaccharides (GOS), a form of non-absorbable fiber mainly found in beans, root vegetables, and some dairy products, can be broken down with alpha-galactosidase. GOS is well-known for its health benefits. However, it might produce gas and bloating in certain people.

These enzymes work with acids and bile to break down food into a state that our bodies can utilize. The digestive process begins in the mouth, where digestive enzymes immediately work on carbohydrates and lipids.

Digestion becomes problematic when the body produces insufficient amounts of one or more digestive enzymes, and you might have undesirable gastrointestinal symptoms.

A doctor may prescribe a medicine or a supplement to restore lost digestive enzymes.

Taking enzyme medicine will assist you in obtaining the necessary nutrients from your diet.

What Does Science Say About Digestive Enzymes?

Enzymes are proteins with rounded shapes that regulate biological reactions. Digestive enzymes help break down food molecules into their component “building blocks.” These reactions take place outside of the gut’s cells.

Enzyme names are assigned using one of two systems:

To the root name of the item being operated upon, the suffix ‘-as is added; for example, a sucrase enzyme is utilized when sucrose is digested.

When sucrase breaks down sucrose into glucose and a fructose molecule, it performs a chemical process. Because this reaction requires the addition of a water molecule to dissolve a chemical bond, the enzyme is known as a hydrolase. This hydrolase class includes all digestive enzymes.

Enzymes are large protein molecules with distinct three-dimensional shapes. A region called the ‘active site’ is embedded within the form and can attract other molecules with similar profiles to bond to it. The analogy of a key fitting into a lock commonly describes this mechanism. The attracted molecule is the key, while the enzyme is the lock.

The products are freed, and the enzyme is free to attract other substrate molecules once the chemical reaction within this lock and key configuration are complete.

The hydrolase family of digestive enzymes is in charge of breaking down large food molecules into their constituent ‘building blocks.’

They’re also extracellular enzymes, meaning they mingle with food as it passes through the colon. The bulk of other enzymes is found in the cell’s cytoplasm.

A broad spectrum of hydrolase enzymes produced by the cells lining the stomach and related organs like the pancreas is required for the chemical digestion of food. The ultimate goal is to break down substantial food molecules into tiny ‘building block’ components. These can then be absorbed easily and quickly through the gut wall and into the bloodstream, where they will be transported to the liver and eventually to other regions of the body.

The salivary glands, stomach, pancreas, liver, & small intestine are the primary enzyme-producing tissues in the human digestive system.

Without the help of digestive enzymes, chemical digestion would be impossible. An enzyme is a protein that helps the body speed up chemical reactions. Digestive enzymes speed up chemical reactions that break down major food molecules into tiny molecules.

You are a regular adolescent who enjoys eating. Your digestive system & endocrine system must function together to break down, absorb, & spread the nutrients from your meal throughout your body. The endocrine system sends hormones throughout your body that link between cells. Hormones are essentially chemical messenger molecules.

The cells that line the stomach and small intestine produce digestive hormones. These hormones enter the bloodstream and can impact other sections of the digestive system. The following is a list of some of these hormones:

  • Gastrin is a hormone that regulates the secretion of stomach acid.
  • Cholecystokinin is a hormone that regulates pancreatic enzyme output.
  • Secretin is a protein that instructs the pancreas to secrete water and bicarbonate.
  • Ghrelin is a hormone that tells you when you’re hungry.

Stomach inhibitory polypeptide is a peptide that inhibits or reduces gastric output. In reaction to high blood glucose levels, it also triggers insulin release.

Since most of the foods we eat are cooked or processed somehow. Therefore the raw foods we eat only contain enough enzymes to process that specific food. Our bodies should produce most of the digestive enzymes we need unless we use supplemental enzymes to help digestion. Various enzyme supplements are available from a range of sources. Understanding the variations between enzyme types is crucial to ensure that you are using the most appropriate enzyme product for your needs.

Reduced digestive distress, higher energy, and enhanced regularity are all advantages of enzyme supplementation:

  • Soothe Digestive Distress: Undigested foods can irritate & potentially harm the sensitive intestinal wall as they pass through the intestines. This discomfort may diminish our digestive capacity & interfere with the crucial absorption process over time.
  • Increase Energy: Up to 80% of our body’s vital energy is wasted on digestion, according to Yuri Elkaim, author of Eating for Energy. You can free up a lot of energy by assisting the breakdown & absorption of nutrients, increasing physical vigor, and boosting energy levels.
  • Promote Regularity: Improving digestion can assist in maintaining a healthy intestinal environment while alleviating constipation and irregularity.

Side Effects of Digestive Enzyme Supplements?

Digestive enzymes are thought to be relatively safe, with few adverse effects. Digestive enzymes, both non-prescribed and prescribed, can cause gastrointestinal side effects such as:

  • nausea
  • diarrhea
  • constipation
  • other stomach problems

Other potential digestive enzyme adverse effects described in the study include:

  • The enzyme chymotrypsin causes allergic responses.
  • The enzyme trypsin causes pain and burning feelings.
  • Gastritis, esophageal problems, and allergic reactions have been linked to the enzyme papain.
  • Cramps and diarrhea in the intestines, as well as allergic reactions to the enzyme bromelain

If you take too many digestive enzymes, the adverse effects can be severe. Too much papain, for example, can induce esophageal rips, whereas raw papain is an irritant that can cause blisters.

FAQs About Digestive Enzymes

Q: What exactly are digestive enzymes, what are their functions?

A: Amylase, lipase, pepsin, trypsin, and other digestive enzymes aid in the breakdown of complex food particles into simpler forms. These tiny molecules are easily absorbed by the bloodstream and delivered to all body cells.

Digestive enzymes are activated in a variety of ways. Pepsin is a digestive enzyme that breaks down proteins in meals into smaller particles like peptide fragments & amino acids. It is created in the inactive form pepsinogen, a zymogen, by the stomach cells known as “principal cells.” The stomach acid then converts pepsinogen to pepsin, the active form.

Q: When it comes to digestive enzymes, how long do they take to work?

A: The digestive enzymes are subsequently released into the small intestine, where they aid in digestion meals. After consuming enzymes, they work for about 45 to 60 minutes. Enzymes aid in the digestion of carbohydrates, proteins, and lipids.

Q: What are the negative consequences of using digestive enzymes?

A: Potential side effects of digestive enzymes include:

  • Nausea, diarrhea, and abdominal cramping are side effects of digestive enzymes.
  • Headache
  • Neck ache
  • Congestion in the nose
  • Legs and feet are swollen
  • Rash

Q: What causes a lack of digestive enzymes?

A: Chronic pancreatitis, cystic fibrosis, celiac disease, diabetes, inflammatory bowel diseases like Crohn’s disease, and gastrointestinal surgery in which sections of the pancreas or stomach have been removed are all conditions that can cause EPI.

Q: Which digestive enzymes are the most important?

A: The following are the most important digestive enzymes:

  • Amylase is one of the most significant digestive enzymes
  • Maltase
  • Lactase
  • Lipase
  • Proteases
  • Sucrase

Q: What happens if enzymes cease to function?

A: The form and function of an enzyme will be harmed if the surrounding environment gets too acidic or basic. Inhibitors can interfere with an enzyme’s capacity to cause a chemical reaction. Natural inhibitors can be identified.

Q: What are some of the advantages of digestive enzymes?

A: Advantages of digestive enzymes are:

  • They could state that they help with digestion
  • Fat, carbohydrate and protein breakdown should all be optimized
  • Ensure that nutrients are absorbed properly
  • Following meals, minimize gas, bloating, indigestion, & constipation
  • aid in the digestion of difficult-to-digest foods
  • Colon health is promoted

Q: What is the best way to tell if digestive enzymes are effective?

A: Many adverse side effects, like indigestion, allergy-like symptoms, or discomfort, are signs that the enzymes are working correctly. The body is purging itself, and the healing process has begun.

Q: How can one naturally boost digestive enzymes?

A: Pineapples, papayas, mangoes, honey, bananas, avocados, kefir, sauerkraut, kimchi, miso, kiwifruit, and ginger are all foods that contain natural digestive enzymes. When incorporated into one’s diet, any of these items may help with digestion & gut health.

Q: What are the four elements that influence the activity of enzymes?

A: Temperature, pH, enzyme concentration, substrate concentration, and the presence of any inhibitors or activators all influence the rate at which enzymatic reactions occur.

Q: How long should digestive enzymes be taken?

A: Consider a two- or three-week trial period if you’re going to attempt digestive enzymes. If it works, you might want to keep doing it.

Q: How can you tell if you’re having digestive issues?

A: One or more of the symptoms listed are frequently the initial sign of digestive problems:

  • Bleeding
  • Bloating
  • Constipation
  • Diarrhea
  • Heartburn
  • Incontinence
  • Nausea and vomiting are common side effects
  • The pain is in the stomach

Q: What are the seven digestion steps?

A: Ingestion, propulsion, mechanical digestion, chemical digestion, absorption, & feces are the digestive processes.

Q: What are the different types of digestive systems?

A: The digestive system’s two major divisions are the alimentary tract and accessory organs. The mouth, pharynx, esophagus, stomach, large and small intestines, rectum, and anus make up the alimentary tract of the digestive system.

Q: Is it possible to consume more than one enzyme product simultaneously?

A: Yes, but only if digestive enzymes are taken with meals and therapeutic enzymes on an empty stomach.

The Top 7 Digestive Enzyme Supplements Summary

Digestive enzymes are proteins that aid in the digestion of food. Salivary glands & cells lining the stomach, pancreas, & small intestine secrete them. Enzymes unlock the nutrients in your meal. Plant foods contain enzymes that aid in digestion and help break down food to provide energy to your body. These essential elements are frequently lacking in modern diets. It’s crucial to eat certain foods in their natural raw state since enzymes are sensitive to their surroundings.

You may have an enzyme shortage if you experience frequent digestive problems or find it difficult to lose weight when eating a balanced diet. When it comes to your gut health, it’s critical to be on the lookout for warning signals so you can take the necessary steps to promote a healthy digestive system and general well-being.

There’s a growing body of evidence demonstrating that the benefits of digestive enzymes are genuine. Taking digestive enzymes can help you increase your body’s ability to digest food thoroughly. Look for nutritional supplements that incorporate enzymes if you want to take a separate supplement to boost your digestive enzymes.

Including enzymes in your supplements will help you get the most out of your nutrients while reducing stomach discomfort. It can provide various benefits, such as relief from digestive distress, acid reflux, dietary intolerances, and increased nutrient absorption.

Try one of the best digestive enzymes above today!

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